结核病与自身免疫性心肌炎相关
Andrea Frustaci1, Lucio Cuoco, Cristina Chimenti
1Department of Cardiology, Catholic University, Rome, Italy. biocard@rm.unicatt.it
Circulation
|June 5, 2002
概括
结核病 (CD) 和心肌炎有着共同的自身免疫联系. 超过4%的心肌炎患者患有CD,对免疫抑制和无质饮食反应良好.
科学领域:
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 结核病 (CD) 和心肌炎与系统性自身免疫性疾病有关.
- 之前没有研究过CD和心肌炎的同时发生.
- 调查这种联系可能会产生重大临床影响.
研究的目的:
- 为了调查乳病 (CD) 和心肌炎的共存.
- 为了确定患有心肌炎的患者中CD标志物的流行率.
- 评估自身免疫过程对心脏和小肠的影响.
主要方法:
- 187名心肌炎患者的血清查心脏自身抗体,抗组织转质胺酶 (IgA-tTG) 和抗内膜性抗体 (AEA).
- 对IgA-tTG和AEA阳性患者进行十二指肠内镜,活检和HLA分析.
- 与306名正常人组成的对照组进行了比较.
主要成果:
- 在187名心肌炎患者中,9名 (4.4%) 检测出AEA阳性,并显示了CD的证据.
- 在心肌炎患者中,CD的患病率明显高于对照组 (4.4%与0.3%,P<0.003).
- 患有心肌炎的心脏病患者经历了心力衰竭或心室节律失常; 免疫抑制和/或无质饮食治疗导致恢复或改善.
结论:
- 影响心肌和小肠的共享自身免疫过程存在于超过4%的心肌炎患者中.
- 免疫抑制和无质饮食是这些患者的有效治疗策略.
- 这项研究强调了CD和心肌炎之间潜在的自身免疫联系.
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