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Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
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通过pVHL在HIF-1α中承认氧的结构基础

Wai-Ching Hon1, Michael I Wilson, Karl Harlos

  • 1Division of Structural Biology, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK.

Nature
|June 7, 2002
PubMed
概括

低氧诱导因子-1α (HIF-1α) 的稳定性通过氧化和与·希佩尔·林道 (VHL) 蛋白结合来调节. 这种相互作用针对HIF-1α进行降解,为缺氧提供治疗点.

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