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3岁儿童的特定呼吸道阻力:一个前性队列研究
Lesley Lowe1, Clare S Murray, Adnan Custovic
1North West Lung Centre, Wythenshawe Hospital, Manchester, UK.
Lancet (London, England)
|June 12, 2002
概括
患有亚托皮父母或个人亚托皮的儿童即使没有症状,也会表现出肺功能受损 (sR(aw)). 这突显了婴儿呼吸系统疾病的早期风险因素.
科学领域:
- 儿科肺病学 儿科肺病学
- 喘研究 喘研究
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 评估幼儿的肺功能对于了解喘发育至关重要.
- 对这个年龄组来说,可行的方法是对特定气道阻力 (sR(aw)) 进行排气测量.
研究的目的:
- 为了确定与早期儿童肺功能下降相关的风险因素.
- 调查婴儿的家长性阿托皮,个人性阿托皮和肺功能之间的关系.
主要方法:
- 一项前性出生队列研究跟踪儿童直到3岁.
- 产前风险分层基于父母的亚托皮状态 (高,中,低风险).
- 特定气道阻力 (sR(aw)) 测量了503名无症状儿童的全身囊造影.
主要成果:
- 与从来没有喘息的儿童相比,喘息的儿童的sRaw显著更高.
- 在从未喘息的儿童中,在风险组之间观察到sR () 的显著差异.
- 具有亚托皮父母的孩子和具有个人亚托皮的孩子表现出更高的sR (aw),表明肺功能受损.
结论:
- 肺功能受损,以较高的sR(aw表示,即使在没有呼吸道症状的情况下,在幼儿时期也存在.
- 父母的阿托皮和个人阿托皮是婴儿肺功能减弱的重要危险因素.
- 母亲喘病史与孩子的亚托皮状态相互作用,影响肺功能.
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