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在孕妇中查因子V莱登突变的成本效益
Peter Clark1, Sara Twaddle, Isobel D Walker
1Department of Transfusion Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. peter.clark@snbts.csa.scot.nhs.uk
Lancet (London, England)
|June 12, 2002
概括
查孕妇V莱登因子 (FVL) 突变是不具有成本效益的. 普遍或选择性查策略无法防止足够的血管事件来证明额外的管理成本.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 卫生经济学 卫生经济学
背景情况:
- 因子V莱登 (FVL) 突变是妊娠期间血管并发症的遗传风险因素.
- 建议在所有孕妇中进行常规查FVL突变,以减轻这些风险.
研究的目的:
- 评估普遍与选择性查孕妇FVL突变的成本效益.
- 为了比较不同的查策略的额外管理成本和预防的血管事件.
主要方法:
- 这是一项前性,非选择性研究,涉及967名孕妇.
- 成本效益分析比较普遍查与选择性查 (基于个人/家族血栓塞瘤病史).
- 假设使用抗凝血剂预防的血管并发症减少了50%.
主要成果:
- 选择性选导致额外的管理成本为3768.8英.
- 全面查需要额外的39,841.1英的管理费用.
- 这些成本导致预防不到一个 (选择性) 和三个 (普遍) 血管事件.
结论:
- 查孕妇是否存在因子V莱登突变并不是一个具有成本效益的策略.
- 与普遍和选择性查相关的额外费用不会导致血管事件的合理减少.
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