通过[18F]-氧葡萄糖正子发射断层扫描对动脉样硬化斑炎的成像
J H F Rudd1, E A Warburton, T D Fryer
1Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
18F-氧葡萄糖 (18FDG) -PET成像可以识别动脉样硬化斑块中的炎症. 与无症状病变相比,有症状的动脉斑块显示出更高的18FDG吸收,表明炎症增加.
科学领域:
- 心血管成像 - 心血管成像
- 核医学是一种核医学.
- 分子成像分子成像技术
背景情况:
- 动脉硬性斑块破裂与炎症有关.
- 目前的成像缺乏对斑块炎症的评估.
- 18F-氧葡萄糖 (18FDG) PET可视化炎症细胞活动.
研究的目的:
- 为了评估18FDG-PET用于成像动脉动脉硬性斑块炎症.
- 为了比较症状与无症状斑块中的18FDG吸收.
主要方法:
- 八名患有症状性动脉样硬化症的患者接受了18FDG-PET和CT成像.
- 在注射后3小时测量了18FDG的摄取量.
- 自主放射学证实了巨细胞中脱氧葡萄糖的积累.
主要成果:
- 通过18FDG-PET可视化了症状性心动脉斑块.
- 18FDG积累在症状斑块中比无症状斑块高27%.
- 正常的动脉没有显示可测量的18FDG吸收.
结论:
- 18FDG-PET成功成像了动脉样硬化斑块炎症.
- 症状,不稳定的斑块显示出更大的18FDG积累.
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