肥胖加快了冠状动脉样硬化在年轻男性的进展
Henry C McGill1, C Alex McMahan, Edward E Herderick
1University of Texas Health Science Center at San Antonio, USA. hmcgill@icarus.sfbr.org
Circulation
|June 12, 2002
概括
肥胖加快了年轻男性的冠状动脉样硬化,强调了体重管理对于预防心脏病的重要性. 这项研究发现,高体重指数与男性心脏病早期症状之间存在显著联系.
科学领域:
- 心血管研究研究心血管研究
- 公共卫生 公共卫生
- 儿童心脏病学 儿童心脏病学
背景情况:
- 肥胖是成人冠状动脉心脏病的已知危险因素.
- 肥胖的患病率在青年和成年人群中都在上升.
- 关于肥胖与动脉样硬化相关的现有研究显示了相互矛盾的结果,特别是在控制其他危险因素时.
研究的目的:
- 调查青少年和年轻人的肥胖和冠状动脉样硬化之间的联系.
- 为了确定与肥胖相关的风险因素是否调解肥胖和动脉样硬化之间的关系.
- 检查肥胖和冠状动脉样硬化之间的性别差异.
主要方法:
- 利用了青少年动脉样硬化病理生物学决定因素 (PDAY) 研究的数据,其中包括大约3000名年龄在15-34岁的人.
- 通过右冠状动脉 (RCA) 的粗病变和美国心脏协会 (AHA) 在左前垂下冠状动脉 (LAD) 的病变等级评估冠状动脉硬化.
- 使用身体质量指数 (BMI) 和骨脂肪厚度测量脂肪,以及其他危险因素,如血清脂质,吸烟,高血压和高血糖症.
主要成果:
- 在年轻男性中,较高的BMI与RCA中脂肪条纹增加和升的病变以及LAD中较高的AHA等级和狭窄相关.
- 肥胖 (BMI > 30 kg/m2) 对RCA升高的病变产生了更明显的影响,在年轻男性中,panniculus adiposus较厚.
- 肥胖与不良的脂质样本,高血压和高血糖,以及吸烟相反地相关;这些因素解释了肥胖对年轻男性冠状动脉样硬化的约15%的影响.
- 在年轻女性中,BMI和冠状动脉样硬化之间没有发现显著的关联,尽管在那些有更厚的腹腺体的女性中观察到趋势.
结论:
- 肥胖与青少年和年轻成年男性的冠状动脉样硬化加速有关.
- 研究结果支持目前的公共卫生工作,重点是控制肥胖,以预防成人冠心病.
- 对年轻男性肥胖的早期发现和干预可能对长期心血管健康至关重要.
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