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Updated: Jul 16, 2026

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一种抑制T细胞发育但却诱导淋巴增殖的LAT突变

Connie L Sommers1, Cheung-Seog Park, Jan Lee

  • 1Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|June 18, 2002
PubMed
概括

激活T细胞的链接蛋白 (LAT) 的突变会破坏T细胞的成熟,并导致自身免疫性疾病. 这突出了LATAT.

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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