与血管风险相关的葡萄酒和酒消费的元分析
Augusto Di Castelnuovo1, Serenella Rotondo, Licia Iacoviello
1Department of Vascular Medicine and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy.
Circulation
|June 19, 2002
概括
轻度到中度的葡萄酒消费显示了与血管风险的显著反向关联. 酒消费也显示出类似的,尽管不太清楚,与降低血管风险的关联.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 营养科学 营养科学
背景情况:
- 流行病学研究已经探索了酒精消费与心血管疾病之间的联系.
- 以前的研究表明,某些酒精饮料对血管风险有潜在的保护作用.
研究的目的:
- 进行一项元分析,评估葡萄酒或酒消费与血管风险之间的关系.
- 量化估计与不同水平的饮料摄入量相关的血管风险.
主要方法:
- 对26项研究进行了元分析,使用了基于一般差异的方法.
- 分析了从提供葡萄酒和酒消费定量血管风险估计的研究中收集的数据.
- 用统计模型来评估剂量-反应关系.
主要成果:
- 葡萄酒摄入量显示,与不饮酒者相比,血管疾病的相对风险为0.68 (13项研究,209,418名参与者).
- 在葡萄酒消费中观察到一个J形关系,每天高达150毫升的显著反向关联.
- 适度酒消费的整体相对风险为0.78 (15项研究,208,036名参与者),但没有发现显著的剂量反应关系.
结论:
- 轻度至中度的葡萄酒消费与血管风险的降低有显著关联.
- 在酒消费方面也观察到类似的,但不那么明显的关联.
- 由于酒缺乏明确的剂量反应关系,因此其解释具有挑战性.
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