与Jarvik 2000植入式轴流左心室辅助系统的初步临床经验
O H Frazier1, Timothy J Myers, Igor D Gregoric
1Cullen Cardiovascular Surgical Research Laboratories, Texas Heart Institute, Houston, USA.
Circulation
|June 19, 2002
概括
贾维克2000轴流为心力衰竭患者提供安全有效的左心室辅助系统 (LVAS). 这种先进的设备改善了血液动力学和生活质量,为移植候选人提供了可行的选择.
科学领域:
- 心血管外科心血管外科
- 生物医学工程 生物医学工程
- 心脏衰竭管理的管理
背景情况:
- 植入式左心室辅助系统 (LVAS) 对于治疗严重心力衰竭至关重要.
- 传统的LVAS存在局限性,影响患者的发病率.
- 轴流是一个有希望的进步,可以改善患者的治疗结果.
研究的目的:
- 评估Jarvik 2000 LVAS的安全性和临床实用性.
- 评估设备对血液动力学和患者功能状态的影响.
主要方法:
- 在10名纽约心脏协会 (NYHA) IV类心脏移植候选人中植入Jarvik 2000.
- 手术方法涉及左胸切除术和部分心肺旁路术.
- 平均支持持续时间为84天.
主要成果:
- 植入后48小时内观察到显著改善:心脏指数增加43%,肺毛细血管压下降52%.
- 患者经历了系统性血管抵抗的减少,并消除了对无otropic 支持的需求.
- 八名患者在康复后实现了NYHA I级,证明了有效的左心室卸载.
结论:
- 贾维克2000功能作为一个有效的辅助装置,通过部分左心室卸载优化血液动力学.
- 初步发现表明,Jarvik 2000 LVAS可以安全地用于心脏移植候选人的循环支持.
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