进化生物学:刺穿过牛的中间线
Alexander J Nederbragt1, André E van Loon, Wim J A G Dictus
1Department of Developmental Biology, Utrecht University, The Netherlands. alexanderj@nederbragt.net
Nature
|June 21, 2002
概括
这项研究提供了证据表明,对脊椎动物中线模式至关重要的刺基因,也表达在皮 (Patella vulgata) 中. 这支持了背中轴逆转理论,这表明神经系统发育的共同进化起源在原始体和后代体中.
科学领域:
- 发育生物学 发展生物学
- 进化生物学 进化生物学
- 神经科学是一个神经科学.
背景情况:
- 背中轴逆转理论提出,原体和后体共享一个共同的祖先与反转的身体计划.
- 这一理论表明,原生体的腹部神经系统和后生体的背部神经系统之间存在同质性.
- 在这两组中,中线模式基因对神经系统发育至关重要.
研究的目的:
- 为了研究一个主要的中线模式基因的表达在一个原始体.
- 为背中轴逆转理论提供实验证据.
- 探索神经系统发育机制的进化保护.
主要方法:
- 研究了一种子基因的正义基因的表达模式.
- 使用的Patella vulgata幼虫作为模型生物.
- 专注于沿背中轴的基因表达.
主要成果:
- 发现对刺的表达是沿着幼虫的腹部 (腹部) 表达的.
- 这种表达模式反映了刺在脊椎动物中线图案中的作用.
- 为保存的中线发展机制提供实验支持.
结论:
- 这些发现支持了神经系统中线发育的共同祖先机制的假设.
- 表明背中轴逆转理论得到了保存的基因表达模式的支持.
- 突出了原生体和后生体神经系统组织之间的进化联系.
相关概念视频
Crossing Over
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
Gastrulation
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Convergent Evolution
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.The structures that arise from convergent evolution are called analogous structures. They are similar in function even if they are dissimilar in structure. Further, structures can be analogous while also...
Evolutionary Relationships through Genome Comparisons
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Hedgehog Signaling Pathway
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...


