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Updated: May 7, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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Published on: January 18, 2017

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Efp针对14-3-3西格玛蛋白质分解,并促进乳腺瘤的生长

Tomohiko Urano1, Tomoyuki Saito, Tohru Tsukui

  • 1Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

Nature
|June 21, 2002
PubMed
概括

雌激素受体点Efp作为一种全方位化酶,降解细胞循环抑制剂14-3-3 sigma. 这促进了依赖雌激素的细胞增殖和乳腺癌的生长.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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