充血性心力衰竭和心肌泌尿素II的表达
Stephen A Douglas1, Lara Tayara, Eliot H Ohlstein
1Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, King of Prussia, Pennsylvania, USA.
Lancet (London, England)
|June 22, 2002
概括
患有充血性心力衰竭 (CHF) 的患者的心脏肌肉中尿素II的表达显著升高,这表明它在心脏功能障碍和重塑中起着作用.
科学领域:
- 心血管研究研究心血管研究
- 分子心脏病学分子心脏病学
- 心脏衰竭病理生理学 病理生理学
背景情况:
- 人体尿素II对心血管系统表现出强大的血管活性,内和高效应.
- 充血性心力衰竭 (CHF) 的特点是复杂的心脏功能障碍和重塑.
- 尿素II在衰竭的人类心脏中的表达和作用仍然不完全理解.
研究的目的:
- 在患有充血性心力衰竭 (CHF) 的患者中研究肌肉中泌尿素II及其受体 (UT受体) 的表达水平.
- 为了将尿素II表达与心力衰竭严重程度的临床参数相关联.
主要方法:
- 心肌组织样本从末期心脏梗塞,早期心脏梗塞和健康对照患者中获得.
- 使用免疫组织化学,现场杂交和RT-PCR来评估尿素II和UT受体表达.
- 使用共聚焦显微镜量化尿素II结合部位.
主要成果:
- 在末期慢性心血管疾病患者的心肌细胞中观察到尿素II的强烈表达,在早期慢性心血管疾病中显著减少,在对照组中最小.
- 尿素II的表达与左心室末端透缩维度增加和射出分数减少相关.
- 在CHF心肌中检测到尿素II度增加和UT受体mRNA的存在,以及结合部位增加.
结论:
- 这些发现表明,在衰竭的人类心脏中,尿素II系统的显著上调.
- 尿素II可能在心脏功能障碍和与充血性心力衰竭相关的不良重塑中发挥关键作用.
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