在土壤中发现了一种流行性Burkholderia cepacia复杂菌株
John J LiPuma1, Theodore Spilker, Tom Coenye
1Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, 8323 MSRB III, Box 0646, Ann Arbor, MI 48109, USA. jlipuma@umich.edu
Lancet (London, England)
|June 22, 2002
概括
Burkholderia cepacia复杂感染对囊性纤维化患者构成威胁. 研究人员在农业土壤和囊性纤维化患者中发现了一种常见的菌株,这表明尽管采取了控制措施,环境来源仍有助于感染.
科学领域:
- 微生物学 微生物学
- 环境科学 环境科学
- 传染性疾病 传染性疾病
背景情况:
- Burkholderia cepacia复合体 (BCC) 导致危及生命的感染,特别是在患有囊性纤维化 (CF) 的人群中.
- 结核病患者之间的交叉感染是主要的传播途径,但正在进行的获取表明环境储库.
- 在CF患者中常见的BCC菌株的环境来源尚未确定.
研究的目的:
- 为了确定Burkholderia cepacia复杂菌株的环境储存库,这些菌株与囊性纤维化感染有关.
- 确定环境菌株是否与引起人类感染的菌株无法区分.
主要方法:
- 利用各种基因造型技术来分析细菌菌株.
- 从农业土壤中分离出来的菌株与美国大西洋中部CF患者中发现的菌株进行了比较.
主要成果:
- 在农业土壤中确定了一种特定的B. cepacia genomovar III菌株.
- 这种土壤衍生的菌株是研究区域中CF患者中最常被发现的BCC菌株.
- 在环境和患者相关的BCC菌株之间证明了基因相似性.
结论:
- 人类致病性BCC菌株不一定与环境菌株有所区别.
- 农业土壤是CF患者BCC感染的潜在储存库.
- 这些发现可能解释了CF患者的持续BCC获得,尽管感染控制协议.
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