支架后冠状动脉压力测量预测了随访时的不良事件:一个多中心注册表
Nico H J Pijls1, Volker Klauss, Uwe Siebert
1Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands. cardiologie.catharina.zks@wxs.nl
Circulation
|June 26, 2002
概括
冠状动脉支架后的分数流量储备 (FFR) 预测了患者的结果. 实现最佳的FFR后造显著减少主要不良事件,突出其在心血管护理的重要性.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 医疗器械 医疗器械
背景情况:
- 冠状动脉支架在6个月内有15-20%的复缩率,尽管进行了最佳的血管造影植入.
- 支架后的生理评估可能会改善患者的治疗结果.
研究的目的:
- 为了研究后支架分流储备 (FFR) 和6个月临床结果之间的关系.
- 为了确定生理支架植入是否改善患者的结果,与单独的血管学评估相比.
主要方法:
- 一个多中心注册750名接受冠状动脉支架的患者.
- 冠状动脉压测量是在静脉支架后最大的高血压时进行的.
- 支架后的FFR被计算出来,并与6个月后的主要不良事件相关联.
主要成果:
- 10.2%的患者经历了重大不良事件 (死亡,心肌梗塞,再血管).
- 支架后的FFR是对不良事件最强的独立预测因素 (P<0.001).
- 事件发生率为FFR>0.95的4.9%,FFR 0.90-0.95的6.2%,FFR <0.90的20.3%,FFR <0.80的29.5%.
结论:
- 支架后的分量流量储备 (FFR) 是6个月后结果的关键独立预测指标.
- 为减少心血管不良事件,优化造后的FFR至关重要.
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