在心脏和雌激素/孕激素替代研究 (HERS) 中,他类药物治疗,心血管事件和总死亡率
David M Herrington1, Eric Vittinghoff, Feng Lin
1Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. dherring@wfubmc.edu
Circulation
|June 26, 2002
概括
在患有心脏病的绝经后妇女中,使用他类药物显著降低了心血管事件,静脉血栓栓塞事件和总死亡率. 这些发现支持对符合条件的冠状动脉疾病妇女进行他类药物治疗.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 妇女健康 妇女健康
背景情况:
- 对于男性来说,他类药物的心血管结果已经确立,但对女性来说却不那么明显.
- 对于他类药物和激素替代疗法 (HRT) 对心血管结局的联合影响仍然不确定.
研究的目的:
- 检查他类药物使用对心血管事件和绝经后患有心脏病的女性死亡率的影响.
- 研究他类药物使用与激素替代疗法 (HRT) 对心血管结果的相互作用.
主要方法:
- 从心脏和雌激素/孕激素替代研究 (HERS) 的数据分析,这是一个随机临床试验.
- 在2763名患有心脏病的绝经后妇女中,非随机比较使用他类药物的人与不使用者.
主要成果:
- 静止剂使用者的主要结局 (非致命性心肌梗塞或冠心病死亡) 的发生率较低 (RH=0.79,P=0.04).
- 立方体使用与总死亡率 (RH=0.67,P=0.003) 和静脉血栓栓塞事件 (RH=0.45,P=0.02) 的显著降低有关.
- 激素替代疗法 (HRT) 在非他类药物使用者中增加了初级事件的早期风险,但在他类药物使用者中没有;调整后的分析显示,HRT对初级结果没有影响.
结论:
- 在患有冠状动脉疾病的绝经后妇女中,使用他类药物与心血管事件,静脉血栓栓塞事件和整体死亡率的减少有关.
- 这些发现强烈支持在现有冠状动脉疾病的符合条件的妇女中使用他类药物.
更多相关视频
相关概念视频
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:27Coronary Artery Disease V: Interprofessional Care
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
01:26Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...