通过高密度测绘研究的隔离子心脏中的多态复入室内心跳动
Lucas Boersma1, Zoltan Zetelaki, Josep Brugada
1Physiology Department, Maastricht University, Maastricht, The Netherlands.
Circulation
|June 26, 2002
概括
多形心室性心力衰竭 (VT) 发生于长期折射性区域内的转移回流电路中. 这项研究表明,耐火期的空间异质性如何引发和维持多态静脉.
科学领域:
- 心血管生理学心血管生理学
- 心脏电生理学 心脏电生理学
- 节律失常的发生 (arrhythmogenesis).
背景情况:
- 多态心室性心力衰竭 (VT) 机制越来越多地与折射性分散和重新进入有关.
- 在受控的2D模型中研究多态心律不整,具有局部延长的折射性.
研究的目的:
- 为了阐明多态心律失常的机制.
- 检查空间异质性在VT起源的耐火期中的作用.
主要方法:
- 在子腹腔表心中使用冷程序创造了区域延长的折射性.
- 在冷却和控制心脏中通过编程刺激诱导多态静脉动脉.
- 高分辨率的心上表皮映射用于分析回入电路动力学.
主要成果:
- 多态VT在所有心脏中都可诱导区域冷却,与对照不同.
- 高分辨率绘图在长时间的折射性区域内确定了功能性回流电路.
- 回流的波面动态地移动,导致节拍对节拍的激发模式发生变化.
结论:
- 转移功能回流回路是多态VT的主要机制.
- 增强的折射性空间异质性作为这些心律失常的基质.
相关概念视频
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