小纤维神经病变在肉类突发症中的发生
E Hoitsma1, M Marziniak, C G Faber
1Department of Neurology, University Hospital Maastricht, Netherlands. ehoi@sneu.azm.nl
Lancet (London, England)
|June 28, 2002
概括
由于小纤维神经病变,一些sarcoidosis患者会经历疼痛和听觉障碍. 定量感官测试和神经纤维密度测量证实了这种情况,通常涉及自主功能障碍.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 沙尔科病是一个可以影响多个器官的炎症性疾病.
- 一些类炎患者报告了无法解释的疼痛和听觉障碍.
- 自主功能障碍也是一种潜在的并发症.
研究的目的:
- 为了调查在有疼痛或自主功能障碍的类菌病患者中存在小纤维神经病变.
- 在这个人群中描述与小纤维神经病变相关的感觉缺陷.
主要方法:
- 量化感官测试 (QST) 对31名型细菌病患者进行了测试.
- 皮内神经纤维密度 (IENFD) 通过7名患者的皮肤活检进行评估.
- QST测量了热敏度 (热和冷).
主要成果:
- 31名患者中有25名 (80.6%) 显示热敏度降低,冷敏度降低或两者兼而有之.
- 与对照组相比,所有接受皮肤活检的7名患者都显示IENFD减少.
- 这些发现表明,受影响的沙尔科毒症患者中存在小纤维神经病变.
结论:
- 小纤维神经病变可能是导致疼痛和听力障碍的原因,在一些萨尔科病患者.
- 自主参与可能与沙尔科毒症中小纤维神经病变共存.
- 进一步的研究是有必要的,以探索细纤维神经病变的机制和管理在沙尔科毒症.
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