大脑白质病变,视网膜病变和发生的临床中风
Tien Yin Wong1, Ronald Klein, A Richey Sharrett
1Department of Ophthalmology, University of Wisconsin, Madison, USA. ophwty@nus.edu.sg
JAMA
|July 2, 2002
概括
与视网膜异常相关的白质病变 (WMLs) 会增加中年成人中风风险. 早期发现WML和视网膜病变可能有助于预测和预防临床中风.
科学领域:
- 神经学 神经学
- 眼科医生 眼科 眼科
- 血管医学 血管医学
背景情况:
- 脑部扫描中的白质病变 (WMLs) 疑似源于微血管问题,并先于中风.
- 现有有限的临床数据证实了WMLs的微血管起源及其对中风的预测价值.
研究的目的:
- 调查WMLs,视网膜微血管变化和临床中风的发生率之间的联系.
- 在一个健康的中年人群中分析这些关系.
主要方法:
- 利用了来自社区动脉样硬化风险研究 (ARIC) 的数据,这是一项基于人口的前性队列.
- 包括1684名年龄在51-72岁之间的参与者,他们接受了脑磁共振成像和视网膜摄影.
- 通过MRI评估WML和视网膜异常,在中位数4.7年的随访期间将它们与发生的中风相关联.
主要成果:
- 视网膜病变的个体显示WML的可能性更高 (OR,2.5).
- 在那些患有WML (RR, 3.4) 和视网膜病变 (RR, 4.9) 的患者中,五年中风发生率较高.
- 与那些没有WML和视网膜病变的人相比,在WML和视网膜病变的个体中观察到明显更高的中风风险 (RR, 18.1).
结论:
- 中年个体的大脑WML与视网膜微血管异常有关.
- WMLs的存在独立地增加了临床中风的风险.
- 同时的WML和视网膜病变显著增加中风风险,强调了脑血管和视网膜健康之间的联系.
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