双胞胎怀孕的结果与完整的水性形和健康的共同双胞胎
Neil J Sebire1, Marianne Foskett, Fernando J Paradinas
1Trophoblastic Disease Unit, Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, London W6 8RF, UK.
Lancet (London, England)
|July 2, 2002
概括
持续的双胞胎怀孕与完整的水性形 (CHM) 和健康的双胞胎携带高自发流产风险. 然而,大约40%的结果是活产,而不会显著增加持续妊娠 trofhoblastic 疾病 (pGTD) 的风险.
科学领域:
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 妇科瘤学 妇科瘤学
- 生殖内分泌学 生殖内分泌学
背景情况:
- 完整的水性形 (CHM) 与一个共存的健康胎儿呈现复杂的管理决策.
- 在这些罕见的双胞胎怀孕中,对母亲和胎儿的风险评估至关重要.
研究的目的:
- 评估与继续与终止与健康的共同双胞胎CHM怀孕相关的风险和结果.
- 在这两种管理策略中确定持续妊娠 trofhoblastic 疾病 (pGTD) 的发生率.
主要方法:
- 追溯评估77例双胞胎怀孕,其中包括CHM和一个健康的共同双胞胎.
- 对妊娠延续率,自发流产,活产以及对pGTD进行化疗的需求进行分析.
主要成果:
- 在53个继续怀孕的怀孕中,28个达到>=24周的怀孕期,导致20个活产.
- 16%的第一季度终止和21%的持续怀孕需要为pGTD进行化疗.
- 在持续的怀孕中观察到高自发流产率.
结论:
- 拥有健康双胞胎的CHM具有明显的自发流产风险.
- 与早期终止相比,继续这些怀孕提供约40%的活产机会,而不会显著增加pGTD的风险.
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