在接受心脏手术的患者中预防术后心房动的干预措施:元分析
Eugene Crystal1, Stuart J Connolly, Khaled Sleik
1Division of Cardiology, Faculty of Health Sciences, McMaster University, Ontario, Hamilton, Canada. crystal@bgumail.bgu.ac.il
Circulation
|July 3, 2002
概括
贝塔抑制剂,索塔醇和阿米奥达龙在心脏手术后有效预防术后心房动 (AF),它们之间没有显著差异. 这些药物还可以减少住院时间 (LOS),而双心节奏表现有前途.
科学领域:
- 心脏病学 心脏病学
- 心脏外科手术 心脏外科手术
- 药理学 药理学 是一个学科.
背景情况:
- 手术后心房动 (AF) 是心脏手术后的常见并发症.
- AF与增加的并发症和更长的住院时间有关.
- 预防AF是一个关键的临床目标.
研究的目的:
- 系统地审查随机试验中关于术后AF的预防疗法的证据.
- 评估药理和非药理干预措施的有效性.
主要方法:
- 对52项随机试验进行系统的文献搜索.
- 包括的干预措施:β-阻断剂,索塔醇,阿米奥达龙和节拍.
- 分析结果:AF预防,停留时间 (LOS) 和中风发生率.
主要成果:
- 贝塔抑制剂 (OR 0.39),索塔醇 (OR 0.35) 和阿米奥达龙 (OR 0.48) 显著预防了AF.
- 双心节拍 (OR 0.46) 在预防AF方面也有效.
- 所有药物干预和双心节奏都显示了减少LOS的趋势;在治疗和对照组之间,中风发病率相似.
结论:
- 贝塔阻断剂,索塔醇和阿米奥达龙在降低手术后的AF风险方面是有效的,有效性相似.
- 这些药物与减少住院时间有关.
- 双心节奏是潜在的新疗法,但需要进一步的关于减轻中风的数据.
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