型肝炎和艾滋病毒疾病的进展
Mark S Sulkowski1, Richard D Moore, Shruti H Mehta
1Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St, Room 448, Baltimore, MD 21287-0003, USA. msulkows@jhmi.edu
JAMA
|July 4, 2002
概括
肝炎C病毒 (HCV) 感染不会显著影响人类免疫缺陷病毒 (HIV) 疾病的进展或对抗逆转录病毒治疗的反应. 这项研究发现,共感染患者和非共感染患者之间在艾滋病定义疾病,死亡风险或免疫恢复方面没有实质性的差异.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 关于型肝炎病毒 (HCV) 对人类免疫缺陷病毒 (HIV) 疾病进展的影响,有相互矛盾的报道.
- 了解共感染效应对于管理艾滋病毒患者至关重要.
研究的目的:
- 评估HCV感染如何影响艾滋病毒疾病的临床和免疫进展.
- 评估HCV对高活性抗逆转录病毒疗法 (HAART) 免疫反应的影响.
主要方法:
- 一项前性队列研究,从1995年至2001年,涉及1955名美国城市艾滋病毒诊所的患者.
- 随访评估了艾滋病定义疾病的进展,存活率和CD4细胞计数的变化.
- 分析考虑了与HCV共感染状态和HAART有效性相关的结果.
主要成果:
- 在感染HCV和未感染HCV的患者之间,没有观察到艾滋病定义疾病或死亡风险的显著差异.
- 虽然CD4计数较低的小组显示出较高的初始死亡风险,但在对HAART进行调整后,这与HCV没有独立相关.
- 接受有效HAART治疗的患者在CD4细胞计数增加方面没有差异,无论HCV共感染状态如何.
结论:
- 在这个美国城市群体中,HCV共感染并没有显著改变死亡风险,艾滋病发病风险或对HAART的免疫反应.
- 研究结果表明,有效的HAART可以减轻HCV共感染对艾滋病毒疾病进展的潜在负面影响.
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