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怀孕激素放松素也是一种由心脏分泌的血管扩展性吗?

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心脏分泌的荷尔蒙放松素大力扩大全身动脉,可能有助于心血管调节. 这种由内皮介导的效应在肺动脉中没有观察到.

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科学领域:

  • 心血管生理学心血管生理学
  • 内分泌学 在内分泌学.

背景情况:

  • 传统上与怀孕相关的荷尔蒙放松素,现在已知是由心脏分泌的.
  • 它在心血管调节中的作用是一个新兴的研究领域.

研究的目的:

  • 为了研究放松素对人类小阻力动脉的影响.
  • 为了比较relaxin在全身和肺循环中的作用.

主要方法:

  • 人类的全身和肺动脉使用线路肌图学进行了研究.
  • 累积度-反应曲线是为放松素和其他血管扩展剂生成的.
  • 通过去除内皮质来评估内皮质的作用.

主要成果:

  • 放松素引起了系统动脉的显著血管扩张 (最大响应66+/-16%).
  • 放松素的血管扩张作用取决于内皮的存在.
  • 放松素在肺动脉中没有显著的血管扩张作用.

结论:

  • 心脏分泌的放松素是人类系统性阻力动脉的强有力的血管扩张剂.
  • 放松素可能在调节全身血压方面发挥作用.
  • 它的作用是针对全身循环的,需要完整的内皮.