冠状动脉的遗传性 冠状动脉量通过电子束计算机断层扫描测量在无症状的成年人
Patricia A Peyser1, Lawrence F Bielak, Julia S Chu
1Department of Epidemiology, University of Michigan, Ann Arbor 48109, USA. ppeyser@umich.edu
在无症状成年人中,遗传因素显著影响冠状动脉化 (CAC) 量,占变化的40%以上. 这突显了遗传影响对亚临床动脉样硬化的重要性.
科学领域:
- 心血管遗传学 心血管遗传学
- 医疗成像医学成像
- 流行病学 流行病学
背景情况:
- 通过电子束计算机断层扫描 (EBCT) 检测到的冠状动脉化 (CAC) 是冠状动脉样硬化的关键标志物.
- CAC数量可以预测无症状个体的心血管事件.
- 传统的风险因素解释了CAC变化的<50%,这表明了遗传的贡献.
研究的目的:
- 量化基因因素和测量风险因素对社区无症状成年人样本中CAC数量的相对贡献.
主要方法:
- 使用电子束计算断层扫描 (EBCT) 来测量CAC数量.
- 分析了302个家庭698名无症状的白人成年人的数据.
- 使用渐进线性回归来识别独立预测因素并调整风险因素.
主要成果:
- 在风险因素调整之前,遗传因素占CAC量变化的43.5% (P=0.0007).
- 即使调整了年龄,性别,血糖,血压,吸烟和LDL胆固醇,遗传因素仍然解释了41.8%的残留变化 (P=0.0003).
结论:
- 遗传因素在亚临床冠状动脉样硬化变异中发挥着重要作用,用CAC数量来衡量.
- 显著的遗传影响表明,影响CAC数量的未发现基因需要进一步调查.
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