在弗雷明汉心脏研究中,腹腔大动脉质沉积物的遗传性得到证据
Christopher J O'Donnell1, Irmarie Chazaro, Peter W F Wilson
1National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Mass 01702, USA. chris@fram.nhlbi.nih.gov
Circulation
|July 18, 2002
概括
遗传因素显著影响腹部大动脉化 (AAC),这是动脉样硬化的一个标志物. 近一半的AAC变异归因于遗传性特征,这表明这种心血管疾病预测因素的遗传基础.
科学领域:
- 心血管遗传学 心血管遗传学
- 动脉样硬化研究 动脉样硬化研究
- 医疗成像医学成像
背景情况:
- 动脉样硬化是一种与心血管疾病相关的全身性疾病.
- 腹腔大动脉化 (AAC) 在X线图上表明动脉样硬化,并预测心血管事件.
- 大动脉化的遗传性在很大程度上仍然没有被描述.
研究的目的:
- 为了研究腹腔大动脉化 (AAC) 的遗传性.
- 确定由遗传和环境因素引起的AAC变异的比例.
主要方法:
- 分析了来自弗雷明汉心脏研究的2151名参与者的横侧腰部放射图.
- 使用经过验证的评级尺度量化腹腔大动脉质 (AAC) 沉积物.
- 使用SOLAR差异组件方法计算家族对 (父母-子女,兄弟姐妹,配偶) 的相关系数和遗传率估计.
主要成果:
- 对AAC的年龄,性别和多变量调整的相关系数为父母-后代0.52,兄弟姐妹对为0.20.
- 估计AAC的遗传率为0.49 (P<0.001),这表明有显著的遗传影响.
- 在AAC沉积物中,49%的总体变异归因于遗传因素,31%归因于测量共变量.
结论:
- 遗传因素对腹腔大动脉化的存在和程度有很大影响.
- AAC变化的很大一部分是由于需要进一步表征的附加遗传效应.
- AAC测量可以作为动脉样硬化遗传研究的遗传定量表型.
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