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Updated: Jul 5, 2026

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
07:33

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS

Published on: December 21, 2011

尼菲迪平通过血管光滑肌肉细胞依赖的途径间接上调内皮细胞中超氧化物脱酶的表达

Keisuke Fukuo1, Jin Yang, Osamu Yasuda

  • 1Department of Geriatric Medicine, Osaka University Medical School, Suita, Osaka, Japan. fukuo@geriat.med.osaka-u.ac.jp

Circulation
|July 18, 2002
PubMed
概括

像尼菲迪平这样的抗体通过增加内皮细胞 (ECs) 中的超氧化失调酶 (SOD) 来改善内皮功能. 这种效应是由血管光滑肌细胞 (VSMCs) 介导的,它们释放血管内皮生长因子 (VEGF).

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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

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Paracrine Signaling

Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
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Cell Specific Gene Expression

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Necrosis

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Regulation of Angiogenesis and Blood Supply

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Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...
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Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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