出生于暴露于多乙的男性的男孩的数量
Iliana del Rio Gomez1, Tom Marshall, Peichien Tsai
1National Cheng Kung University Medical College, Tainan 70428, Taiwan.
Lancet (London, England)
|July 20, 2002
概括
在20岁之前暴露于多双 (PCB) 的人在尤石油灾难的男性与较少的男性出生有关. 父亲暴露于PCB可能会影响后代的性别比率.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 流行病学 流行病学
背景情况:
- 1979年在台湾发生的尤石油灾难导致了广泛接触多二 (PCB) 的情况.
- 了解像PCB这样的环境污染物的长期健康影响对于公共健康至关重要.
- 父亲对环境毒素的暴露与生殖结果有关.
研究的目的:
- 调查父亲和母亲接触PCB和他们的孩子的性别比率之间的联系.
- 为了确定父亲PCB暴露的时间 (成年前或后) 是否影响后代的性别比率.
主要方法:
- 追溯对涉及于尤石油灾难的个人进行的队列研究.
- 暴露与未暴露男性和女性后代的男性与女性出生比例的比较.
- 使用几率比率和置信区间来评估风险的统计分析.
主要成果:
- 父亲在20岁前接触PCB的风险与生男孩的可能性显著降低 (或0.65).
- 20岁后父亲接触PCB的情况显示,男性与女性的性别比率与对照组相似 (OR 0.90).
- 与未暴露的母亲相比,暴露的母亲所产生的后代在出生时的性别比率中没有明显的差异 (OR 0.93).
结论:
- 父亲暴露于PCB,特别是在20岁之前,可能会对后来的孩子的性别比例产生不利影响,使其倾向于更多的女性出生.
- 在男性中,PCB暴露的时间似乎至关重要,成人前暴露具有更明显的效果.
- 母亲PCB暴露对本研究群体出生时的性别比率没有显著影响.
相关概念视频
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