连接染色体,危机和癌症
Richard S Maser1, Ronald A DePinho
1Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, M413, Boston, MA 02115, USA.
Science (New York, N.Y.)
|July 27, 2002
概括
癌细胞破坏了基因组的稳定性,端粒功能障碍导致了染色体异常. 了解端粒危机机制可以导致新的癌症治疗方法.
科学领域:
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 癌症的特点是基因组不稳定.
- 癌细胞操纵的分子机制,维护基因组完整性.
- 端粒在癌症中起着双重作用,有可能启动或抑制癌症.
研究的目的:
- 探索端粒在癌症启动和抑制中的对比作用.
- 审查证据,将端粒功能障碍与癌症基因组异常联系起来.
- 讨论端粒危机在产生癌症发病的基因改变中的作用.
主要方法:
- 关于癌症中的端粒生物学的文献综述.
- 对驱动染色体异常的端粒功能障碍证据的分析.
- 探索细胞危机和癌症发作中的DNA损伤检查点.
主要成果:
- 端粒功能障碍是癌症染色体异常的关键驱动因素.
- 细胞通过关闭检查点的危机产生突变,从而引发癌症.
- 端粒诱导的危机是癌症发展的关键机制.
结论:
- 端粒功能障碍显著导致癌症基因组不稳定.
- 了解端粒危机和管理对于开发新型癌症疗法至关重要.
- 针对端粒诱导危机可能为癌症和其他疾病提供新的治疗策略.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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