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Updated: Mar 19, 2026

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
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Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

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交换N-CoR核心压缩剂和Tip60联合激活剂复合体,将NF-kappaB和β-粉样蛋白前体蛋白的基因表达链接起来

Sung Hee Baek1, Kenneth A Ohgi, David W Rose

  • 1Howard Hughes Medical Institute, Department of Molecular Medicine, La Jolla, CA 92093, USA.

Cell
|August 2, 2002
PubMed
概括

介质蛋白-1β触发核心压缩复合物的核出口,激活特定的基因,如KAI1.1. 这揭示了一种涉及粉样蛋白前体蛋白在基因调节中的新途径.

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The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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