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Updated: Jul 30, 2026

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
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Published on: March 29, 2019

基因沉默:染色质中的跨素调节通路

Scott D Briggs1, Tiaojiang Xiao, Zu-Wen Sun

  • 1Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

Nature
|August 2, 2002
PubMed
概括

在H2B的基因组位化作用为基因沉默的主开关. 这一过程调节了关键的基因素甲基化模式,特别是控制了基因素H3在Lys 4和Lys 79的甲基化.

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Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
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