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Updated: May 11, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
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Published on: October 30, 2015

对T细胞受体识别MHC的两步结合机制

Lawren C Wu1, Delphine S Tuot, Daniel S Lyons

  • 1Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, B221 Beckman Center, Stanford, California 94305, USA.

Nature
|August 2, 2002
PubMed
概括

T细胞受体 (TCR) 通过两步过程扫描-MHC复合体. 主体组织相容性复合体 (MHC) 相互作用指导初始对接,而接触稳定结合,确保T细胞特异性和交叉反应性.

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