缺血性心肌缺血后缩短:积极收缩或被动反弹?
Helge Skulstad1, Thor Edvardsen, Stig Urheim
1Institute for Surgical Research and Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway.
Circulation
|August 7, 2002
概括
缺血性心肌中静脉缩短后的缩短可以表明活跃的收缩和活力,特别是在低动力段. 应变多普勒回声心脏学有效量化这一点,有助于识别可行的心脏组织.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 心肌活性的活力.
背景情况:
- 静心后缩短 (PSS) 是一种建议的缺血性心肌活力的标志物.
- 需要澄清PSS (主动收缩与被动反弹) 的确切机制及其通过应变多普勒回声心脏图 (SDE) 的量化.
研究的目的:
- 要确定PSS是否代表活性纤维缩短或被动反弹.
- 评估SDE是否可以准确量化PSS.
主要方法:
- 在麻醉的狗中,测量了左心室 (LV) 压力,心肌长轴应变 (SDE) 和细分长度 (声微仪).
- 在LV压力段长度和LV应力段长度循环分析中,在LAD狭窄和闭塞期间定义了活性收缩.
主要成果:
- LAD狭窄增加了PSS,分析表明它在低动力/动性段中活跃.
- LAD封闭导致动力障碍,PSS在某些部分变为被动反弹.
- 在测量PSS (r=0.83) 时,SDE与声微量计有很好的相关性.
结论:
- 皮质神经系统是非特异性的;它可以在动力障碍的部分是被动的,但在低动力/动的部分是活跃的.
- 低动力/无动力段中的活跃PSS意味着活跃收缩,可行的心肌.
- SDE是一种可行的临床工具,用于量化PSS和确定心肌活力.
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