肠道激素PYY(3-36) 在生理上抑制食物摄入
Rachel L Batterham1, Michael A Cowley, Caroline J Small
1Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
Nature
|August 9, 2002
概括
肠道激素YY(3-36) (PYY(3-36) 通过激活下丘脑中的Y2受体 (Y2R) 来减少食物摄入量和体重增加. 这一发现突出了对食欲调节的关键肠-下垂体通路.
科学领域:
- 神经内分泌学神经内分泌学
- 调节食欲 调节食欲是什么意思
- 胃肠道激素 胃肠道激素
背景情况:
- 食物摄入的下丘脑调节涉及黑色皮质素和神经Y (NPY) 系统.
- NPY Y2受体 (Y2R) 在弧形核中的NPY神经元上高度表达,这是一个关键的食欲控制中心.
- YY(3-36) (PYY(3-36) 是一种Y2R激动剂,在食后从肠道释放出来.
研究的目的:
- 为了研究外围PYY的作用,在调节食物摄入量和体重.
- 为了确定PYY(3-36) 的厌食效应是否由Y2受体介导.
主要方法:
- 在老鼠和小鼠 (包括Y2r-null小鼠) 中对PYY的外周和内弓内注射.
- 测量食物摄入量,体重增加和下丘脑Npy信使RNA水平.
- 使用c-Fos免疫反活性和电生理学评估神经元活动.
主要成果:
- 周围PYY(3-36) 给药抑制了大鼠和野生类型小鼠的食物摄入量,并减少了体重增加.
- 这些效应在Y2r-null小鼠中不存在,证实了Y2R的重要作用.
- PYY ((3-36) 降低了下丘脑Npy mRNA,增加了弧形核c-Fos表达,并抑制了NPY神经末端活动,表明POMC神经元激活.
结论:
- 餐后PYY ((3-36) 通过弧形核Y2R作用,抑制食.
- PYY ((3-36) 代表了调节食欲的肠-海马体通路中的关键信号分子.
- 在人类中注入PYY ((3-36) 显著降低了食欲和食物摄入量,支持其生理作用.
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