曼诺胺,一种来自Streptomyces hygroscopicus的新型抗菌糖,LL-AC98

Haiyin He1, R Thomas Williamson, Bo Shen

  • 1Department of Natural Products Chemistry, Chemical Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA. heh@wyeth.com

概括

新型曼诺胺 (1-5) 对MRSA和VRE等耐药细菌表现出强烈的活性. 它们独特的结构,包括一种不寻常的氨基酸和曼诺,是它们抗菌功效的关键.

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