控制的光化学释放氧化从O2-基替代的二二甲酸盐中释放
Patrick H Ruane1, K Mani Bushan, Christopher M Pavlos
1Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
Journal of the American Chemical Society
|August 15, 2002
概括
研究人员探索了对diazeniumdiolates的光敏感保护组. 超电子捐赠组增强了二酸盐光释放,使得可控的NO-捐赠化学反应成为可能.
科学领域:
- 有机化学 有机化学
- 摄影化学的使用.
- 药用化学 医学化学
背景情况:
- 二甲酸盐是多功能氧化 (NO) 供体.
- 控制保护组的光化学作用对于它们的应用至关重要.
- 用O2-基替代的二氧化二甲酸盐经常经历不必要的光解途径.
研究的目的:
- 为了研究对diazeniumdiolates的光敏保护组.
- 为了确定元电子捐赠群对O2-基替代型二二甲酸盐的光化学的影响.
- 为了增强可控NO输送的diazeniumdiolates的光释放.
主要方法:
- 甲基替代的O2-基二氧化二氧化的光解.
- 1H NMR光谱用于直接观察光释放的二二甲酸盐.
- 在高和低pH溶液中量化氧化 (NO).
主要成果:
- 基因基衍生物的光解主要产生了氨酸和氧氨酸.
- 超电子捐赠替代剂显著改善了二酸盐光释放.
- 光释放的程度与pi-donating元替代剂的强度相关.
- 观察到的NO释放率与热分解一致,并显示了pH的依赖性.
结论:
- 甲基替代有效调整了O2-基二二甲酸盐的光化学.
- 更强大的pi捐赠元组促进了大量的二二酸盐光释放.
- 这一策略为从基于二二酸盐的系统中控制NO释放提供了一条途径.
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