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在异构性家族性高胆固醇血症和对他类药物治疗的反应中增加了残留样颗粒
Pernette R W de Sauvage Nolting1, Marcel B Twickler, Geesje M Dallinga-Thie
1Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. p.desauvagenolting@amc.uva.nl
Circulation
|August 15, 2002
概括
在家族性高胆固醇血症 (FH) 患者中,残留脂蛋白胆固醇 (RLP-C) 显著升高. 立方体治疗降低了RLP-C,但水平仍然很高,表明需要进一步的治疗策略.
科学领域:
- 心血管医学 心血管医学
- 脂质学 脂质学是指脂质学.
- 遗传学 遗传学 是一个
背景情况:
- 其余脂蛋白 (RLP-C) 在动脉动脉生成中发挥作用.
- 升高的RLP-C与动脉样硬化疾病的进展有关.
- 在家族性高胆固醇血症 (FH) 中RLP-C的存在和对他类药物的反应以前在大型队列中尚未确立.
研究的目的:
- 评估FH患者的RLP-C水平.
- 评估他类药物治疗对FH的RLP-C的影响.
主要方法:
- 从36个脂质诊所招募了327名FH患者.
- 经过6周的洗后,在2年内使用80毫克的simvastatin单疗法.
- 在治疗前和治疗后使用免疫分离试验测量RLP-C水平.
主要成果:
- 在FH患者表现出严重升高的总胆固醇,LDL胆固醇和RLP-C在基线.
- 西姆瓦斯塔丁治疗使RLP-C水平降低了49% (P<0.0001).
- 即使在正常的甘油三水平的FH患者中也观察到升高的RLP-C,这与异位原体特征相关.
结论:
- 在FH患者中,基线RLP-C水平明显升高.
- 西姆瓦斯塔丁显著降低RLP-C,但水平没有正常化.
- 在FH中RLP-C的升高可能源于LDL受体功能障碍,并有助于腺原性特征,表明需要加强治疗.
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