新生儿暴露于重复的脚跟刺伤的条件和过敏症
Anna Taddio1, Vibhuti Shah, Cheryl Gilbert-MacLeod
1Department of Pharmacy, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8. anna.taddio@sickkids.on.ca
JAMA
|August 21, 2002
概括
出生于患有糖尿病的母亲的婴儿暴露在重复的痛苦手术中显示出增加的疼痛反应. 这表明新生儿可以学会预测疼痛,从而导致超痛症.
科学领域:
- 新生儿护理 新生儿护理
- 儿科疼痛研究的研究.
- 内分泌学 在内分泌学.
背景情况:
- 住院的婴儿经常经历侵入性手术.
- 累积疼痛暴露对新生儿疼痛行为和超痛症的影响尚不清楚.
研究的目的:
- 为了调查糖尿病母亲的新生儿是否经历了重复的疼痛,发展出预期性疼痛行为.
- 为了比较糖尿病母亲的婴儿与正常婴儿在手术期间的疼痛反应.
主要方法:
- 一项前性队列研究比较了21名糖尿病母亲的婴儿和21名正常婴儿.
- 患有糖尿病的母亲的婴儿经历了反复的跟刺,以监测血糖.
- 在静脉穿刺和肌内维生素K注射期间的疼痛反应被评估,使用面,哭泣时间和视觉模拟尺度 (VAS) 评分.
主要成果:
- 患有糖尿病的母亲的婴儿在皮肤清洁 (P=.03) 和静脉穿刺 (P=.01) 期间表现出显著更多的微笑.
- 在静脉穿刺期间,在糖尿病母亲的婴儿中观察到更高的视觉模拟尺度 (VAS) 评分 (P=.002) 和哭泣时间 (P=.03).
- 在肌内注射维生素K后,没有发现疼痛反应的显著差异.
结论:
- 糖尿病母亲的新生儿暴露在重复的脚跟刺伤中,表现出预期疼痛行为.
- 与正常婴儿相比,这些婴儿在静脉穿刺期间表现出较高的疼痛反应.
- 早期的疼痛暴露可能导致疼痛感知的长期变化.
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