运动诱导的巴罗反射灵敏度增加预测了心肌梗塞后的预后改善
Maria Teresa La Rovere1, Chiara Bersano, Marco Gnemmi
1Centro Medico di Montescano, Fondazione Salvatore Maugeri IRCCS, Montescano, Pavia, Italy.
Circulation
|August 21, 2002
概括
运动训练通过增加阴道活动来改善心肌梗塞 (MI) 后患者的生存率,这种活动通过巴罗反射灵敏度 (BRS) 来衡量. 这表明自主平衡与长期心脏结果之间存在联系.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 自主神经科学 自主神经科学
背景情况:
- 证据表明运动训练对心肌梗塞 (MI) 后存活率的益处是有限的.
- 阴道活动减少与患者死亡风险增加有关.
- 狗的运动训练改善了阴道反射,并防止了突然死亡.
研究的目的:
- 测试运动训练与增加阴道活动 (通过巴罗反射灵敏度或BRS表示) 结合,是否会降低后心脏病患者的死亡率.
- 研究改善自主平衡对心脏病发作后长期存活率的影响.
主要方法:
- 在95名男性患者中,幸存下来的第一个无并发性心脏病发作被随机分配到4周的耐力训练或没有训练.
- 巴罗反射灵敏度 (BRS) 被测量为自主平衡的指标.
- 心脏病死亡率在10年的随访期内被跟踪.
主要成果:
- 4周后,受过训练的患者在BRS中显著改善了26% (P=0.04),而未受过训练的患者则没有.
- 经过训练的患者,运动诱导的BRS增加>= 3ms/mm Hg (响应者) 在10年内心脏死亡率显著降低 (0%对23%,P=0.04).
- 无论训练状态如何,受访者都显示心脏病死亡率有所改善 (4%对24%,P=0.04).
结论:
- 在心脏病发作后的运动训练可以提高长期生存率.
- 这种生存益处取决于阴道活动的显著增加,由改善的BRS证明.
- 增加的BRS是有利的自主转移和心脏病后心脏病死亡率降低的关键标志物.
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