基于支架的方法用于心室到冠状动脉旁路
Peter Boekstegers1, Philip Raake, Rasul Al Ghobainy
1Department of Internal Medicine I, Grosshadern University Hospital, Munich, Germany. boekstegers@med1.med.uni-muenchen.de
Circulation
|August 21, 2002
概括
一种新的基于支架的腹腔到冠状动脉旁路 (VSTENT) 程序在猪模型中在冠状动脉封闭期间有效地保护了心肌功能和血液流动.
科学领域:
- 心血管外科心血管外科
- 生物医学工程 生物医学工程
- 干预心脏病学 干预心脏病学
背景情况:
- 腹腔到冠状动脉绕道 (VCAB) 是一种实验性的重血管化技术.
- VCAB主要为冠状动脉提供静脉血流.
研究的目的:
- 开发和评估一种基于支架的程序 (VSTENT),用于创建VCAB.
- 评估VSTENT在冠状动脉狭窄和闭塞的情况下保护心肌动脉血流和功能方面的疗效.
主要方法:
- 在猪模型中,在左心室和左前垂下冠状动脉 (LAD) 之间植入了一个覆盖式支架 (VSTENT).
- 在不同程度的LAD狭窄和完全封闭期间测量了远端LAD流量,区域心肌功能和冠状动脉压力.
- 研究了VSTENT定位和潜在的门式透气机制对流量保存的影响.
主要成果:
- 在LAD封闭3小时内,VSTENT保持了基线净向前流量的70±6%和区域肌肉功能的71±8%.
- 流量保存受到VSTENT定位的影响,当在透气过程中存在类似门的机制时,流量保存得到增强.
- 在显著的LAD狭窄 (>70%) 时,静态输入占主导地位,平均静态冠内压与净流量线性相关 (r=0.88,P<0.001).
结论:
- 基于支架的心室至冠状动脉旁路 (VSTENT) 是一个可行的程序.
- 在LAD完全封闭期间,VSTENT成功地保持了显著的心肌血流和心肌功能.
- 由VSTENT定位产生的透气式机制和与狭窄动脉中残留透气流的有利相互作用有助于有利的结果.
相关概念视频
Coronary Circulation
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Imaging Studies for Cardiovascular System V: CT
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Cardiac Catheterization II: Right Heart Catheterization
Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
Cardiac Catheterization III: Left Heart Catheterization
Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
Coronary Artery Disease IV: Preventive Measures
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease V: Interprofessional Care
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...


