在左心室壁的除冲击期间,通过光学绘制膜电位的光学映射来评估内膜虚拟电极
Vladimir G Fast1, Oleg F Sharifov, Eric R Cheek
1Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Ala 35294, USA. fast@crml.uab.edu
Circulation
|August 21, 2002
概括
除冲击会在心脏内部产生显著的跨膜潜在变化 (DeltaV(m)) .
科学领域:
- 心血管生理学心血管生理学
- 电子生理学 电子生理学
- 生物医学工程 生物医学工程
背景情况:
- 根据理论,除动脉的机制涉及心室肌肉中的冲击诱导的跨膜潜在变化 (DeltaV(m)).
- 在除过程中缺乏这些室内DeltaV (m) 的实验证据.
研究的目的:
- 在除过程中实验测量左心室 (LV) 内内冲击诱导的DeltaV(m).
- 为提供虚拟电极假设的第一个直接实验证明.
主要方法:
- 使用光二极管阵列的光学映射测量隔离猪LV制剂中的跨度DeltaV (m).
- 在动力电位平原期间,应用了受控的矩形电击 (10毫秒持续时间,2-50V/cm).
主要成果:
- 微弱的冲击 (大约. 2V/cm) 产生了可以忽略不计的室内DeltaV.
- 较强的冲击 (>4V/cm) 诱导了不对称的室内DeltaV (m),负潜力往往大于正潜力.
- 非常强大的冲击 (>34V/cm) 导致整个跨壁面的DeltaV (m) 主要是负的,而不依赖于冲击极性.
结论:
- 强烈的除冲击显然会在左心室的内壁层中诱导显著的DeltaV (m).
- 在动作潜能高原期间,内腔DeltaV (m) 通常是不对称的,并且在非常强大的冲击时可以变得全局负面.
更多相关视频
06:57Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
Published on: January 31, 2019
16.6K
10:17Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
Published on: April 11, 2025
2.4K
相关概念视频
01:21The Resting Membrane Potential
Overview
01:24Resting Membrane Potential
The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...