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星爆亚马克林细胞树突中的方向选择性信号
Thomas Euler1, Peter B Detwiler, Winfried Denk
1Max Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany. tueler@mpimf-heidelberg.de
Nature
|August 23, 2002
概括
视觉中的方向选择性是在星爆亚马克林细胞中计算的. 这些细胞的单个树突分支作为独立的模块,在到达质细胞之前处理运动方向.
科学领域:
- 神经科学是一个神经科学.
- 视觉科学 视觉科学 视觉科学
- 细胞生物学 细胞生物学
背景情况:
- 图像运动检测对于许多物种的视觉处理至关重要.
- 视网膜质细胞的方向选择性得到了充分证实,但其细胞起源仍然不清楚.
- 星爆亚马克林细胞被假设是这个过程中的关键内部神经元.
研究的目的:
- 为了研究在视网膜中的定向选择性计算的细胞部位.
- 为了确定星爆亚马克林细胞是否有助于方向选择性.
- 阐明星爆亚马克林细胞树突在视觉运动处理中的作用.
主要方法:
- 两光子光学记录星爆亚马克林细胞中的细胞内的度.
- 在对视觉刺激的反应中分析树突信号和体膜电压.
- 在视网膜制剂中的体内电生理学记录.
主要成果:
- 星爆亚马克林细胞的单个树突分支作为独立的计算单元起作用.
- 在树突性信号中观察到方向选择性,但在体膜电压中没有.
- 从细胞 soma 中离心移动的刺激引起了树突中的选择性反应.
结论:
- 视网膜的方向选择性是局部计算的,在星爆亚马克林细胞的树突分支内.
- 这种计算发生在细胞阶段,先于视网膜质细胞.
- 星爆亚马克林细胞是第一个表现出运动方向选择性的视网膜神经元.
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