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FOXP2的分子进化,这是一种参与言语和语言的基因
Wolfgang Enard1, Molly Przeworski, Simon E Fisher
1Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D-04103 Leipzig, Germany.
Nature
|August 23, 2002
概括
FOXP2基因对人类语言发育至关重要. 研究表明,人类FOXP2的特定变化表明它是在人类进化过程中被选择的,影响了语音和语言能力.
科学领域:
- 进化生物学是进化的生物学.
- 遗传学 是一个遗传学.
- 语言学的语言学.
背景情况:
- 语言是一种独特的人类特征,对文化至关重要.
- 发音需要喉和口腔的精细运动控制,而这种控制在猿类中是没有的.
- 福克斯P2基因是第一个与人类语言能力相关的基因.
研究的目的:
- 研究FOXP2基因在人类语言发育中的作用.
- 为了比较跨物种的FOXP2基因,并分析人类遗传变异.
- 为了确定FOXP2是否在人类进化过程中经历了最近的选择.
主要方法:
- 在人类,黑猩猩,大猩猩,猩猩, rhesus macaques 和小鼠中编码FOXP2蛋白的互补DNA的测序.
- 将人类FOXP2cDNA与其他物种的DNA进行比较.
- 研究人类FOXP2基因内部的物种内变异.
主要成果:
- 在FOXP2的一个点突变与严重的发音和语言障碍有关.
- 两份功能性FOXP2拷贝似乎是正常口语语言获取所必需的.
- 人类FOXP2表现出氨基酸变化和核酸多态,表明最近的阳性选择.
结论:
- FOXP2基因在人类言语和语言的进化中起着至关重要的作用.
- 有证据表明,在最近的人类进化过程中,FOXP2一直处于选择压力之下.
- 像FOXP2这样的遗传因素对人类语言能力的发展至关重要.
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