席尔德纳菲尔对运动,神经激素激活和充血性心力衰竭的勃起功能障碍的影响:双盲,安慰剂控制,随机研究,随后进行勃起功能障碍的前性治疗
Edimar Alcides Bocchi1, Guilherme Guimarães, Amilcar Mocelin
1Heart Failure Clinics, Heart Institute, São Paulo University Medical School, São Paulo, Brazil. dcledimar@incor.usp.br
Circulation
|August 28, 2002
概括
西尔德纳菲尔有效治疗患有充血性心力衰竭 (CHF) 的男性勃起功能障碍 (ED),改善运动能力和生活质量. 这种药物耐受性很好,可以减少身体活动期间的心脏工作负担.
科学领域:
- 心脏病学 心脏病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 勃起功能障碍 (ED) 是诊断为充血性心力衰竭 (CHF) 的患者中普遍存在的疾病.
- 勃起障碍显著降低了患者的生活质量,并可能对治疗坚持产生负面影响,可能阻碍心血管疾病管理的有效性.
研究的目的:
- 为了研究西尔德纳菲尔在治疗男性心脏不全症时的疗效和安全性.
- 评估西尔代纳菲尔对该患者群体的运动能力和心血管参数的影响.
主要方法:
- 一项随机,双盲,安慰剂控制,双向交叉研究,涉及23名患有心血管衰竭的男性.
- 参与者接受了心肺运动测试 (6分钟的步行测试和最大运动测试),有和没有西尔代纳菲尔.
- 使用国际勃起功能指数 (IIEF) 和运动性能指标来评估有效性.
主要成果:
- 西尔德纳菲尔在运动前和运动期间显著降低了心率和血压.
- 药物减轻了运动期间心率的增加,并改善了峰值氧气消耗 (VO2) 和运动持续时间.
- 在国际勃起功能指数得分中观察到显著改善,表明ED治疗有效.
结论:
- 西尔德纳菲尔是一种耐受性良好的,有效的治疗男性心脏衰竭的ED.
- 这种药物增强了运动能力,并可能减少肌肉心脏在运动期间的氧气需求.
- 这些发现表明,西尔德纳菲尔可以改善性功能和身体表现在CHF患者.
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