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β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
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在怀孕期间背手静脉中α-相比β-上腺素敏感度的不成比例下降有利于血管扩张.

Ruth Landau1, Victor Dishy, Alastair J J Wood

  • 1Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Circulation
|August 28, 2002
PubMed
概括

怀孕会降低静脉对α1-上腺体血管收缩和β2-上腺体血管扩张的敏感性. 这种改变的上腺反应有助于怀孕期间观察到的特征性血管扩张.

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科学领域:

  • 生理学 生理学 生理学
  • 药理学 药理学是指药理学的学科.
  • 产科 产科 产科 产科 产科

背景情况:

  • 改变对上腺激素激动剂的血管反应对于妊娠期间的血压和胎盘血流调节至关重要.
  • 在确定血管度方面,α1-adrenergic血管收缩和β2-adrenergic血管扩张相互反对.

研究的目的:

  • 在怀孕期间和之后同时评估手背静脉中的α-上腺体血管收缩和β-上腺体血管扩张.
  • 了解上腺敏感性在与怀孕有关的血管变化中的作用.

主要方法:

  • 研究了20名健康的孕妇 (32-37周怀孕) 和12周产后.
  • 使用线性变量微分变压器技术在手背静脉中测量了对烯 (PE) 和异二醇 (ISO) 的血管反应.
  • 确定PE诱导的收缩和ISO诱导的血管扩张的剂量反应关系.

主要成果:

  • 与分娩后 (0.4μg/min) 相比,在怀孕期间 (2.7μg/min) 的α-上腺素敏感性 (PE CD50) 降低了7倍 (P<0.01).
  • 在怀孕期间,β-上腺体血管扩张减弱,具有更高的ISO ED50 (20 ng/min vs. 8 ng/min) 和更低的最大响应 (81% vs. 105%) (分别P<0.05和P<0.01).

结论:

  • 正常的怀孕表现出静脉敏感性降低,无论是α1-adrenoceptor介导的血管收缩和β2-adrenoceptor介导的血管扩张.
  • 与β2-上腺体反应相比,α1-上腺体反应的较大减少可能解释了人类怀孕中典型的血管扩张状态.