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相关概念视频

Novel and Innovative Hybrid Technique for Type A Aortic Dissection06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

847
The protocol describes ascending aortic replacement combined with endovascular coverage of the entire aortic arch with a fenestrated stent graft in a patient with acute type A aortic dissection in the absence of a tear in the aortic...
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Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft05:25

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

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This study presents a surgical porcine model of chronic myocardial ischemia due to progressive coronary artery stenosis, resulting in impaired cardiac function without infarction. Following ischemia, animals undergo off-pump coronary artery bypass graft with epicardial placement of stem cells-derived exosomes-laden collagen patch. This adjunctive therapy improves myocardial function and...
1.2K
Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit07:04

Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit

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This protocol describes the steps for the creation of a rabbit model with two elastase-digested aneurysms with different hemodynamics (stump and bifurcation constellation). This allows the testing of novel endovascular devices in aneurysms with different angioarchitecture and hemodynamic conditions within a single animal.
2.5K
A Chronic Cardiac Ischemia Model in Swine Using an Ameroid Constrictor08:22

A Chronic Cardiac Ischemia Model in Swine Using an Ameroid Constrictor

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The purpose of this protocol is to demonstrate the placement of a delayed constricting device (an ameroid constrictor) around a coronary artery in a swine model. This device creates an ischemic area of the heart that is useful for studying new diagnostic imaging techniques and new methods of treatment.
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Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA)13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA)

19.1K
Surgical correction of ALCAPA is highly recommended, regardless of age or the degree of intercoronary collateralization. This protocol presents a technique for the direct re-implantation of adult-type ALCAPA into the aorta to re-establish the dual-coronary perfusion. Whenever feasible, direct re-implantation is preferred to other surgical correction...
19.1K
A New Murine Model of Endovascular Aortic Aneurysm Repair08:51

A New Murine Model of Endovascular Aortic Aneurysm Repair

14.7K
Histological and biochemical modifications after aneurysm endograft exclusion are still unclear. We describe a new model of endograft implantation on a murine aneurysm. Through thrombus analysis with and without persistant circulating blood stream interface, and new endovascular biomaterials evaluation, this model will help to better understand endovascular aneurysm exclusion...
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相关实验视频

Updated: Jan 17, 2026

Author Spotlight: Enhancing Coronary Artery Revascularization
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Author Spotlight: Enhancing Coronary Artery Revascularization

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在突触可塑性期间,Ras和Rap控制AMPA受体贩运.

J Julius Zhu1, Yi Qin, Mingming Zhao

  • 1Cold Spring Harbor Laboratory, 1 Bungtown Road, NY 11724, USA.

Cell
|August 31, 2002
PubMed
概括

拉斯和拉普小GTPases通过控制AMPA受体贩运来独立调节突触可塑性. 拉斯在长期强化期间促进AMPA受体的递送,而Rap在长期抑郁期间调解它们的去除.

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 突触性可塑性 突触性可塑性

背景情况:

  • AMPA受体的贩运对于突触可塑性至关重要.
  • 控制这种贩运的信号通路尚未得到充分理解.
  • 像Ras和Rap这样的小GTPases与神经元功能和精神障碍有关.

研究的目的:

  • 调查Ras和Rap小GTPases在突触后信号传递中的作用.
  • 阐明它们在突触可塑性期间贩运AMPA受体的参与.

主要方法:

  • 研究了Ras和Rap在突触后信号传递中的功能.
  • 研究了它们在突触可塑性期间对AMPA受体递送和移除的影响.

主要成果:

  • 在长期强化过程中,Ras传递NMDA受体和CaMKII信号,用于AMPA受体的突触传递.
  • 在长期抑郁期间,Rap调解了依赖NMDA受体的AMPA受体去除.
  • 拉斯和拉普在AMPA受体上起作用,具有不同的亚单元组成.

结论:

  • 拉斯和拉普作为突触可塑性的独立调节者.

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Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA
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  • 它们通过AMPA受体贩运的独特机制控制中心突触的强化和抑制.