在代谢网络中模块化的层次组织
E Ravasz1, A L Somera, D A Mongru
1Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA.
概括
细胞组织依赖于功能模块,但它们的网络结构尚不清楚. 这项研究揭示了代谢网络形成等级模块,这种模式可能在所有细胞系统中都是常见的.
科学领域:
- 系统生物学 系统生物学
- 生物化学 生物化学
- 网络科学 网络科学
背景情况:
- 细胞组织被认为涉及离散的功能模块.
- 复杂的生化网络中模块化的定量证据是有限的.
研究的目的:
- 研究代谢网络的拓组织.
- 为了确定代谢网络是否表现出模块化和层次结构.
主要方法:
- 对43种不同的生物体的代谢网络进行分析.
- 网络理论的应用来识别拓模块.
- 网络架构与已知大肠杆菌的代谢功能进行比较.
主要成果:
- 代谢网络被组织成许多小的,高度相互连接的模块.
- 这些模块按层次组合在一起,形成更大,更不紧密的结构.
- 模块的分布和聚类遵循一个功率定律.
- 在大肠杆菌中发现的模块化与已知的代谢功能保持一致.
结论:
- 代谢网络具有层次化的模块化架构.
- 这种网络结构为细胞组织中的功能模块提供了定量支持.
- 观察到的网络架构可能代表系统级细胞组织的一般原则.
相关概念视频
Levels of Organization
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules comprise...
Functional Groups
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
Functional Groups
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
Functional Groups
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
Levels of Communication II: Organizational, Public, and Group Dynamics
Effective communication is the foundation of a good organization. Communication is the lifeblood of an organization that connects the group with messages. In an organization, communication occurs in upward, downward, and horizontal lines. Downward communication travels from the administrative and senior levels to the staff through official channels such as manuals, rules and regulations, and organizational charts. Staff members initiate upward communication, which is addressed to executives and...
Structural Organization of the Human Body: An Overview
It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...


