合成高度替代的C6和C7乙烯酸乙和乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙烯酸乙
Jerry Evarts1, Eduardo Torres, Philip L Fuchs
1Contribution from the Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Journal of the American Chemical Society
|September 13, 2002
概括
合成Enantiopure环氧乙烯硫,并作为性构建块. 这些化合物使替代环基的立体特异合成成为可能,为复杂分子构建提供了多功能途径.
科学领域:
- 有机化学 有机化学
- 不对称的合成方法
背景情况:
- 环氧乙烯硫是有价值的合成中间体.
- 的构建块对于选择性合成至关重要.
研究的目的:
- 使用雅各布森环氧化方法开发纯环氧硫 (SS-9a,SS-9b).
- 用这些化合物作为构建替代环基的模板.
- 为了探索它们的实用性,作为enones的合成等价物.
主要方法:
- 雅各布森对2-硫1,3-环合和环合二烯的环氧化.
- 对环氧乙烯硫添加碳核的立体特异性添加.
- 构建了与alpha,beta和gamma替代的环基.
主要成果:
- 在SS-9a和SS-9b中添加高产量和立体特异性的碳核友.
- 效率高的构建的反粉替代循环基.
- 证明了环氧乙烯硫作为多功能的性合成剂.
结论:
- 通过雅各布森环氧化,Enantiopure环氧乙烯硫很容易获得.
- 这些硫是合成复杂环基的有效合模板.
- 该方法提供了一个强大的工具,用于循环enones的不对称合成.
相关概念视频
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