接触系统激活在患有血管炎的儿童
Robin Kahn1, Heiko Herwald, Werner Müller-Esterl
1Department of Paediatrics, Lund University, Lund, Sweden.
Lancet (London, England)
|September 21, 2002
概括
患有血管炎的儿童显示接触系统的激活,由布拉迪基宁水平的增加表明. 这表明接触系统在血管炎的发病和炎症和胀等症状中起作用.
科学领域:
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
- 儿科 儿科 儿科
背景情况:
- 接触系统启动了kallikrein-kinin级联,释放了布拉迪基宁.
- 接触系统组件具有促进炎症和血管活性的特性.
- 血管炎涉及血管壁炎症,分子机制不明.
研究的目的:
- 为了研究小儿血管炎患者的接触系统激活.
- 探索接触系统激活和血管炎症状之间的联系.
主要方法:
- 将17名患有血管炎的儿童与21名健康对照进行了比较.
- 通过免疫洗分析了高分子量素蛋白解.
- 使用ELISA量化血布拉迪基宁和肝素结合蛋白 (HBP);对基因的染色活检.
主要成果:
- 在13/17名患者和1/21名对照组 (p<0.0001) 中观察到广泛的高分子量基因蛋白解.
- 患者血布拉迪基宁度显著更高 (中位数为320 ng/L) 与对照组 (11 ng/L) 相比 (p=0.0004).
- 患者的HBP水平升高 (17.4微克/L) 与对照 (6微克/L) (p=0.008);在炎症组织中释放局部激素.
结论:
- 接触系统的激活与血管炎的发病有关.
- 这种激活可以解释血管炎患者的炎症,疼痛,血管扩张和.
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