在根除了Helicobacter pylori之后,最小的残留低度的MALT型胃淋巴瘤
Wolfgang Fischbach1, Mariele Goebeler-Kolve, Petr Starostik
1Department of Internal Medicine II, Klinikum Aschaffenburg, 63739 Aschaffenburg, Germany. wolfgang.fischback@klinikum-aschaffenbug.de
Lancet (London, England)
|September 21, 2002
概括
成功根除Helicobacter pylori可以导致局部低度胃MALT淋巴瘤的良好自然过程. 观察和等待策略可能适合在H. pylori治疗后患有持续性淋巴瘤的患者.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 局部低度胃MALT淋巴瘤通常用Helicobacter pylori根除治疗.
- 在H. pylori根除后可能会出现持久性淋巴瘤,这引发了关于进一步管理的问题.
研究的目的:
- 在成功根除H. pylori后拒绝进一步瘤治疗的患者中描述胃MALT淋巴瘤的自然过程.
- 评估观察和等待策略对持久性疾病的潜力.
主要方法:
- 一系列病例描述了7名患有H.pylori根除后的持续性胃MALT淋巴瘤的患者.
- 纵向观察,平均随访时间为34个月 (范围为22-44个月).
主要成果:
- 所有七名患者都表现出持续的淋巴瘤克隆性.
- 在随访期间没有观察到淋巴瘤进展或高度转变的病例.
- 在所有观察到的患者中,疾病的发展过程是有利的.
结论:
- 观察和等待策略似乎是管理局部低度胃MALT淋巴瘤的有效方法,在H.pylori根除后持续克隆性.
- 在所有情况下,可能不需要进一步的瘤治疗,这表明了不那么积极的管理途径.
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