在持续的发育性口吃中,与语言相关的大脑区域的断开
Martin Sommer1, Martin A Koch, Walter Paulus
1NeuroImage Nord, Department of Neurology, University of Hamburg, Hamburg, Germany.
Lancet (London, England)
|September 21, 2002
概括
持续的发育性口吃可能源于大脑中白质管道的破坏,影响语言的产生. 这项研究表明,神经元通信受损是口吃的基础,而不仅仅是半球主导问题.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 语音科学 语言科学
背景情况:
- 持续发育性口吃的根本原因尚不清楚.
- 假设包括左半球主导性减少导致右半球过度活化,或左半球内的主要赤字.
- 之前的研究表明左半球语言区域的时间干扰,表明神经元通信受损,可能是由于白质干扰.
研究的目的:
- 调查与语音相关的皮质区域之间的结构性断开是否是持续发育性口吃的基础.
- 为了确定的人的特定大脑结构差异.
主要方法:
- 对15个持续发育性口吃的个体和15个匹配的对照进行语音分析,以量化口吃的严重程度.
- 扩散张力成像 (DTI) 用于检查大脑组织的微观结构.
- 用两个样本的t测试来比较口吃和对照组之间的扩散特征.
主要成果:
- 在口吃组和对照组之间观察到扩散特征的显著差异.
- 这些差异位于左感觉运动皮层的喉和舌头表示区域下方.
- 发现分数异构的平均差异为0.04 (95% CI 0.03-0.05).
结论:
- 持续发育性口吃与发言相关大脑区域的激活时间受损有关.
- 这些发现表明,右半球的过度活化可能是一种补偿反应,类似于在失言症中观察到的模式.
- 语音相关途径的结构性断开被认为是口吃的关键因素.
相关概念视频
The Tongue and Taste Buds
The surface of the tongue is covered with various small bumps called papillae, which either distribute what has been ingested (filiform papillae) or contain the sensory taste (or gustatory) receptor cells (fungiform, circumvallate, and foliate papillae). Embedded within each taste-related papilla are the taste buds—clusters of 30 to 100 gustatory receptor cells.
Higher Mental Functions of the Brain: Language
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Deglutition
Swallowing, otherwise known as deglutition, facilitates the transport of food from the mouth to the stomach. It is a multifaceted process that involves both the tongue and the muscles of the throat and esophagus. Saliva and mucus aid in this process, which takes approximately 4 to 8 seconds for semi-solid or solid food and around 1 second for liquids or very soft food.
Swallowing can be divided into three stages: the voluntary phase, the pharyngeal phase, and the esophageal phase. Although the...
Swallowing can be divided into three stages: the voluntary phase, the pharyngeal phase, and the esophageal phase. Although the...
Language Development
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
Language and Cognition
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
Psychosexual Stages of Personality: Oral
The oral stage is the initial phase of Sigmund Freud's theory of psychosexual development, occurring from birth to approximately 12 to 18 months. During this period, the infant's mouth serves as the primary source of pleasure, with actions such as sucking, chewing, biting, and drinking playing a crucial role in reducing tension. These activities are essential not only for nourishment but also for the infant's psychological and emotional satisfaction.
Weaning, typically occurring around the age...
Weaning, typically occurring around the age...


