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相关概念视频

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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相关实验视频

Updated: Jul 16, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
07:54

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

在威尔姆斯瘤中,染色体1q表达概况和复发.

Yong-Jie Lu1, Sandra Hing, Richard Williams

  • 1Section of Paediatrics, Institute of Cancer Research and Royal Marsden Hospital NHS Trust, Sutton, UK.

Lancet (London, England)
|September 21, 2002
PubMed
概括

使用比较表达序列杂交 (CESH) 的基因表达概况确定了威尔姆斯瘤复发的关键指标. 染色体1长臂上过度表达的基因强烈预测了患者的不良结果.

科学领域:

  • 在瘤学瘤学.
  • 遗传学 是一个遗传学.
  • 分子生物学分子生物学

背景情况:

  • 基因表达模式对于准确的瘤分类和预后至关重要.
  • 威尔姆斯瘤是一种常见的儿科癌,需要可靠的方法来预测患者的结果.
  • 识别与瘤行为相关的特定遗传标记对于向治疗至关重要.

研究的目的:

  • 评估一种新的基因表达特征分析技术,比较表达序列杂交 (CESH),其预测威尔姆斯瘤复发的能力.
  • 为了确定特定的染色体基因表达模式是否与瘤行为和患者预后相关.
  • 评估CESH在识别具有瘤发育关键基因的染色体区域中的有用性.

主要方法:

  • 用比较表达序列杂交 (CESH) 来分析18例威尔姆斯瘤的基因表达.
  • 该研究侧重于具有有利组织学发现的瘤.
  • 基因表达水平与患者复发和缓解状态相关.

主要成果:

  • 在染色体1长臂基因的相对过度表达和瘤复发之间发现了显著的关联.
  • 所有复发患者的瘤都表现出这种过度表达,而没有一个缓解的患者表现出这种过度表达 (几率比 357).
  • 这一发现强调了威尔姆斯瘤复发的强有力的预测价值.

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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Last Updated: Jul 16, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

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11:12

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

结论:

  • 比较表达序列杂交 (CESH) 分析是快速选与差异基因表达相关的染色体区域的宝贵工具.
  • 在染色体1长臂上发现的过度基因表达是预测威尔姆斯瘤复发的潜在生物标志物.
  • CESH促进了对瘤行为至关重要的基因的识别,有助于预后,并可能指导治疗策略.